For use only with a single dose powdered drug vial with a 20 mm closure.
Do not administer unless drug is completely dissolved and drug vial is empty. Do not remove drug vial at any time prior to or during administration.
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The amount of water that can permeate from inside the container into the overwrap is insufficient to affect the solution significantly.
Solutions in contact with the plastic container may leach out certain chemical components from the plastic in very small amounts; however, biological testing was supportive of the safety of the plastic container materials.
Plus Container is a sterile, nonpyrogenic solution for intravenous administration after admixture with a single dose powdered drug. Each 100 m L contains 900 mg of Sodium Chloride, USP (Na Cl). The reconstituted drug is then transferred from the vial into the container diluent and mixed to result in an admixture for delivery to the patient. Exposure to temperatures above 25°C/77°F during transport and storage will lead to minor losses in moisture content. It is unlikely that these minor losses will lead to clinically significant changes within the expiration period.
Trissel's 2 Clinical Pharmaceutics Standard Operating Procedures Formulas Physicochemical Flavorings Discontinued Medications Filter Membrane Compatibility Oral Vehicles Base-Salt-Ester Weight Conversion Na Cl Equivalent Values Veterinary Transdermals p H Adjustment Chemotherapy Vial Reconstitution and Stability Preservatives and Antioxidants Article Search Interactive Claim Form The sciences are what support pharmacy's expertise in drug distribution and drug use.0.9% Sodium Chloride Injection, USP is indicated as a source of water and electrolytes and may also be used as diluent for reconstitution of a powdered drug product packaged in a vial with a 20 mm closure. Sodium Chloride Injection, USP should be used with great care, if at all, in patients with congestive heart failure, severe renal insufficiency, and in clinical states in which there exists edema with sodium retention.In patients with diminished renal function, administration of Sodium Chloride Injection, USP may result in sodium retention.It allows for drug admixture after connection to a .A breakaway seal in the tube between the vial adaptor and the container is broken to allow transfer of the diluent into the vial and reconstitution of the drug.However, biological testing was supportive of the safety of the plastic container materials.