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Acute lymphoblastic leukemia (ALL) is the most common malignancy diagnosed in children, representing more than a quarter of all pediatric cancers.
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By common usage, the term chemotherapy has come to connote the use of rather non-specific intracellular poisons, especially related to inhibiting the process of cell division known as mitosis, and generally excludes agents that more selectively block extracellular growth signals (i.e. To avoid these connotations for recently developed (against specific molecular or genetic targets) therapies which inhibit of growth-promoting signals coming from classic endocrine hormones (primarily estrogens for breast cancer and androgens for prostate cancer) is known as hormonal therapy, while the inhibition of other growth-promoting influences (especially those associated with receptor tyrosine kinases) is known as targeted therapy.
Importantly, the use of drugs (whether chemotherapy, hormonal therapy or targeted therapy) constitutes systemic therapy for cancer in that they are introduced into the blood stream and are therefore in principle able to address cancer at any anatomic location in the body.
However, the different forms of ALL require different approaches for optimal results.
Treatment of subclinical CNS leukemia is an essential component of ALL therapy.
To restore access and understand how to better interact with our site to avoid this in the future, please have your system administrator contact [email protected] the review, the risks and benefits of these choices are discussed to determine whether and by what means to proceed to HSCT in adult patients with ALL who are in CR1.Presented are two patients with ALL and a discussion of how the data we provide would lead to a decision about the selection of therapy.Invasive pulmonary aspergillosis accounts for 90–98% of invasive infections.Extra-pulmonary aspergillosis may be present in 25–60% of cases and is almost universally described in the context of disseminated diseases .A 32-year-old woman with no significant past medical history presented to her physician with a 2-week history of abdominal discomfort, a 20-pound weight loss over 2 months, and hepatosplenomegaly.